Fos-related antigen 1 (FRA1) is a protein that in humans is encoded by the FOSL1 gene.
Function
The Fos gene family consists of 4 members: c-Fos, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.
Interactions
FOSL1 has been shown to interact with USF1 (human gene) and C-jun.
See also
- AP-1 (transcription factor)
References
Further reading
External links
- FOSL1 protein, human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- FactorBook FOSL1
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
